The study of the sulphomucopolysaccharides out of mytilus galloprovincialis (lmk)

Abstract

The content and the properties of the sulphomucopolysaccharides (MPS) from Mytilus galloprovinclalis have been studied. Out of 1 kg dry tissue 5.9 g of partially purified mucopolysaccharide were obtained, having 3.71% N, 1.37% S, 2.25% hexuronic acid, 11.7% humidity and 9.3% residuum on calcination.

The study of the toluidine blue coloring function of the MPS concentration in the sample shows firstly the moving of the extinction maximum from 620 to 585nm, then, on bigger MPS concentrations to 625nm. From a pharmaceutical point of view, the anticoagulant activity in comparison with the heparin is insignificant. The preparation shows an intense antilipidic and anticholesterolemic activity on rat, against the tritonic hyperlipidemy, A protective effect against the increase of the optical density of the serum, against hyperlipidemy and hyperoholesterolemy determined by Triton A 20 are noticed. The coloring properties with toluidine-blue, the very small anticoagulant action and the protective effect in experimented hyperlipidemy and hypercholesterolemy situate the MPS from Mytilus galloprovincialis in the same group with the mucopolysaccharides from the digestive tractus of cattle pork and fowl.