Some properties of the pepsin natural inhibitor extracted from the marine gastropod Rapana thomassiana grosse
Keywords:
antipeptic activity, Rapana thomasianaAbstract
A natural inhibitor of pepsin, developing an intensive antipeptic activity, was separated and purified from the marine gastropod Rapana thomasiana Grosee; the value of the inhibition constant, ki, is only 0,009 mg/ml. This inhibitor is of peptidic nature, reacts almost instantaneously with the enzyme and causes an inhibition of the noncompetitive type as related to the hemoglobin used as a substrate. The inhibition developed is a function of the inhibitor concentration in the reaction medium and does not depend on the purity of the preparation used.
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